Serum CA-125 for Early Prediction of Miscarriage

Miscarriage is defined as pregnancy loss before 20 weeks, or fetus less than 500 grams before the age of viability [1], with more than 4 fifth occurring in the first trimester [2]. Threatened miscarriage affects one fifth of women, with the uncertainty about its prognosis, many biochemical markers have been studied to predict its outcome [3]. However, the differentiation of normal and abnormal pregnancy remains a clinical challenge, with no conclusive biochemical marker used before sonographic diagnosis is established which might need several weeks of follow up [4].